Irf6 directs glandular lineage differentiation of epidermal progenitors and promotes limited sweat gland regeneration in a mouse burn model
نویسندگان
چکیده
منابع مشابه
3D bioprinted extracellular matrix mimics facilitate directed differentiation of epithelial progenitors for sweat gland regeneration.
UNLABELLED Sweat glands perform a vital thermoregulatory function in mammals. Like other skin appendages, they originate from epidermal progenitors. However, they have low regenerative potential in response to injury, and whether adult epidermal progenitors could be specified to differentiate to a sweat gland cell lineage remains largely unexplored. We used bioprinting technology to create a fu...
متن کاملThe Potential of Menstrual Blood-Derived Stem Cells in Differentiation to Epidermal Lineage: A Preliminary Report
BACKGROUND Menstrual blood-derived stem cells (MenSCs) are a novel source of stem cells that can be easily isolated non-invasively from female volunteered donor without ethical consideration. These mesenchymal-like stem cells have high rate of proliferation and possess multi lineage differentiation potency. This study was undertaken to isolate the MenSCs and assess their potential in differenti...
متن کاملIdentification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair
Sweat glands are abundant in the body and essential for thermoregulation. Like mammary glands, they originate from epidermal progenitors. However, they display few signs of cellular turnover, and whether they have stem cells and tissue-regenerative capacity remains largely unexplored. Using lineage tracing, we here identify in sweat ducts multipotent progenitors that transition to unipotency af...
متن کاملSweat gland adenocarcinoma of the scalp: A case report
Sweat gland adenocarcinoma is a relatively uncommon malignancy. Clinical features are painless red or violet papules and nodules that can occasionally become ulcerated. The biological behavior is aggressive and metastatic sweat gland carcinoma spreads through the lymphatic. The treatment of choice is wide surgical excision with regional lymph node dissection. The portrayed ase was a 60-year-old...
متن کاملthe potential of menstrual blood-derived stem cells in differentiation to epidermal lineage: a preliminary report
background menstrual blood-derived stem cells (menscs) are a novel source of stem cells that can be easily isolated non-invasively from female volunteered donor without ethical consideration. these mesenchymal-like stem cells have high rate of proliferation and possess multi lineage differentiation potency. this study was undertaken to isolate the menscs and assess their potential in differenti...
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ژورنال
عنوان ژورنال: Stem Cell Research & Therapy
سال: 2018
ISSN: 1757-6512
DOI: 10.1186/s13287-018-0929-7